缺氧诱导因子调控的铁死亡及其在胃肠道疾病中的作用研究进展

doi:10. 20223 / j. cnki. 1000-8535. 2026. 01. 003

摘要/Abstract

摘要： 铁死亡是一种以铁依赖性脂质过氧化为特征的程序性细胞死亡形式。近年来研究表明,铁死亡与缺氧应答的关键调控因子——缺氧诱导因子（HIF）存在密切关联。HIF（包括HIF-1α、HIF-2α、HIF-3α三种亚型）调控的铁死亡在结直肠癌、胃癌、溃疡性结肠炎及其他胃肠黏膜损伤性疾病中发挥作用,影响疾病的发生发展。但目前关于HIF-铁死亡通路在不同胃肠道疾病中的差异化作用及调控机制尚未完全阐明。因此,本文对HIF各亚型调控铁死亡的分子机制及其在胃肠道疾病中的作用进行综述,以期为靶向HIF-铁死亡通路治疗相关疾病提供新的思路。

关键词: 铁死亡, 缺氧诱导因子, 结直肠癌, 溃疡性结肠炎, 胃癌

Abstract: Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation.Recent studies have demonstrated a close association between ferroptosis and hypoxia-inducible factor（HIF）,the key regulator of the hypoxic response.Ferroptosis regulated by HIF（comprising three isoforms：HIF-1α,HIF-2α,and HIF-3α）plays a role in colorectal cancer,gastric cancer,ulcerative colitis,and other gastrointestinal mucosal injury diseases,impacting their initiation and progression.However,the differential roles and regulatory mechanisms of the HIF-ferroptosis pathway in various gastrointestinal diseases remain incompletely elucidated.Therefore,this review summarizes the molecular mechanism networks through which individual HIF isoforms regulate ferroptosis and their roles in gastrointestinal diseases,with the aim of providing new perspectives for targeting the HIF-ferroptosis pathway to treat relevant diseases.

Key words: ferroptosis, hypoxia-inducible factors, colorectal cancer, ulcerative colitis, gastric cancer

牛孟迪, 赵思羽, 赵澈, 肖莉, 孙丽新. 缺氧诱导因子调控的铁死亡及其在胃肠道疾病中的作用研究进展[J]. 广州医药, 2026, 57(1): 16-23.

NIU Mengdi, ZHAO Siyu, ZHAO Che, XIAO Li, SUN Lixin. Research progress in hypoxia-inducible factor regulated ferroptosis and its implications in gastrointestinal disease[J]. Guangzhou Medical Journal, 2026, 57(1): 16-23.

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